Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers

Abstract Alzheimer’s disease (AD) and related tauopathies are associated with pathological tau protein aggregation, which plays an important role in neurofibrillary degeneration and dementia. Targeted immunotherapy to eliminate pathological tau aggregates is known to improve cognitive deficits in AD...

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Bibliographic Details

Published in:	npj Vaccines
Main Authors:	Wenzhi Tan, Jayalakshmi Thiruppathi, Seol Hee Hong, Sao Puth, Sophea Pheng, Bo-Ram Mun, Won-Seok Choi, Kyung-Hwa Lee, Hyun-Sun Park, Duc Tien Nguyen, Min-Cheol Lee, Kwangjoon Jeong, Jin Hai Zheng, Young Kim, Shee Eun Lee, Joon Haeng Rhee
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-06-01
Online Access:	https://doi.org/10.1038/s41541-024-00904-1