Biotransformation of the Mycotoxin Zearalenone to its Metabolites Hydrolyzed Zearalenone (HZEN) and Decarboxylated Hydrolyzed Zearalenone (DHZEN) Diminishes its Estrogenicity In Vitro and In Vivo

Zearalenone (ZEN)-degrading enzymes are a promising strategy to counteract the negative effects of this mycotoxin in livestock. The reaction products of such enzymes need to be thoroughly characterized before technological application as a feed additive can be envisaged. Here, we evaluated the estro...

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Bibliographic Details

Published in:	Toxins
Main Authors:	Sebastian Fruhauf, Barbara Novak, Veronika Nagl, Matthias Hackl, Doris Hartinger, Valentina Rainer, Silvia Labudová, Gerhard Adam, Markus Aleschko, Wulf-Dieter Moll, Michaela Thamhesl, Bertrand Grenier
Format:	Article
Language:	English
Published:	MDPI AG 2019-08-01
Subjects:	zearalenone estrogen response element gene expression cell proliferation estrogen receptor biotransformation
Online Access:	https://www.mdpi.com/2072-6651/11/8/481