Roxadustat as a Hypoxia-Mimetic Agent: Erythropoietic Mechanisms, Bioanalytical Detection, and Regulatory Considerations in Sports Medicine

Roxadustat (ROX) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHI) that exerts erythropoietic, cardioprotective, and metabolic regulatory effects. Approved for the treatment of anemia associated with chronic kidney disease, ROX promotes endogenous erythropoietin...

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Bibliographic Details

Published in:	Current Issues in Molecular Biology
Main Authors:	Elena-Christen Creangă, Cristina Ott, Alina-Crenguţa Nicolae, Cristina Manuela Drăgoi, Raluca Stan
Format:	Article
Language:	English
Published:	MDPI AG 2025-09-01
Subjects:	roxadustat erythropoietin chronic kidney disease hypoxia-inducible factor prolyl hydroxylase inhibitor bioanalysis Quechers method
Online Access:	https://www.mdpi.com/1467-3045/47/9/734