The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol

IntroductionThe inflammatory response after spinal cord injury (SCI) is an important contributor to secondary damage. Infiltrating macrophages can acquire a spectrum of activation states, however, the microenvironment at the SCI site favors macrophage polarization into a pro-inflammatory phenotype,...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	José Lentilhas-Graça, Diogo J. Santos, João Afonso, Andreia Monteiro, Andreia G. Pinho, Vera M. Mendes, Marta S. Dias, Eduardo D. Gomes, Rui Lima, Luís S. Fernandes, Fernando Fernandes-Amorim, Inês M. Pereira, Nídia de Sousa, Jorge R. Cibrão, Aline M. Fernandes, Sofia C. Serra, Luís A. Rocha, Jonas Campos, Tiffany S. Pinho, Susana Monteiro, Bruno Manadas, António J. Salgado, Ramiro D. Almeida, Nuno A. Silva
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	spinal cord injury macrophages secretome neuroimmunology neuroregeneration
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1354479/full