Thrifty wide-context models of B cell receptor somatic hypermutation

Somatic hypermutation (SHM) is the diversity-generating process in antibody affinity maturation. Probabilistic models of SHM are needed for analyzing rare mutations, understanding the selective forces guiding affinity maturation, and understanding the underlying biochemical process. High-throughput...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	eLife
المؤلفون الرئيسيون:	Kevin Sung, Mackenzie M Johnson, Will Dumm, Noah Simon, Hugh Haddox, Julia Fukuyama, Frederick A Matsen
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	eLife Sciences Publications Ltd 2025-08-01
الموضوعات:	B-cell receptors somatic hypermutation convolutional neural networks
الوصول للمادة أونلاين:	https://elifesciences.org/articles/105471