Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice

Pulmonary premature ageing and fibrogenesis as in idiopathic pulmonary fibrosis (IPF) occur with the DNA damage response in lungs deficient of telomerase. The molecular mechanism mediating pulmonary alveolar cell fates remains to be investigated. The present study shows that naturally occurring agei...

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出版年:	Cells
主要な著者:	Kexiong Zhang, Lihui Wang, Xiaojing Hong, Hao Chen, Yao Shi, Yingying Liu, Jun Liu, Jun-Ping Liu
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2021-10-01
主題:	telomerase RNA component telomere shortening lung alveolar type 2 cells senescence apoptosis differentiation
オンライン･アクセス:	https://www.mdpi.com/2073-4409/10/11/2892