Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration

Abstract Mitochondrial proteins CHCHD10 and CHCHD2 are mutated in rare cases of heritable FTD, ALS and PD and aggregate in tissues affected by these diseases. Here, we show that both proteins form amyloid fibrils and report cryo-EM structures of fibrils formed from their disordered N-terminal domain...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Guohua Lv, Nicole M. Sayles, Yun Huang, Chiara Mancinelli, Kevin McAvoy, Neil A. Shneider, Giovanni Manfredi, Hibiki Kawamata, David Eliezer
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Online Access:	https://doi.org/10.1038/s41467-025-62149-3