Somatic hypermutation shapes the viral escape profile of SARS-CoV-2 neutralising antibodiesResearch in context

Summary: Background: Since the onset of the COVID-19 pandemic, SARS-CoV-2 neutralising monoclonal antibodies (mAbs) are being developed for clinical use. With the appearance of new virus variants, most mAbs lost their virus-neutralising activity, highlighting the complexity of mAb development under...

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Bibliographic Details

Published in:	EBioMedicine
Main Authors:	Matthias Bruhn, Maureen Obara, Mariana Gonzalez-Hernandez, Wencke Reineking, Abdus Salam, Monica Mirolo, Imke Hinrichs, AhmedElmontaser Mergani, Yannic Bartsch, Axel Schambach, Gert Zimmer, Wolfgang Baumgärtner, Albert D.M.E. Osterhaus, Ulrich Kalinke
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Subjects:	Viral escape SARS-CoV-2 Monoclonal antibodies Somatic hypermutation Binding affinity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396425002142