Generation of a conditional cellular senescence model using proximal tubule cells and fibroblasts from human kidneys

Abstract Emerging evidence highlights cellular senescence’s pivotal role in chronic kidney disease (CKD). Proximal tubule epithelial cells (PTECs) and fibroblasts are major players in CKD and serve as cellular sources of senescence. The generation of a conditionally immortalized human kidney cell mo...

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Bibliographic Details

Published in:	Cell Death Discovery
Main Authors:	Xiaohang Shao, Huaming Xu, Hyojin Kim, Sadaf ljaz, Fabian Beier, Vera Jankowski, Michaela Lellig, Lucia Vankann, Jan Niklas Werner, Lu Chen, Susanne Ziegler, Christoph Kuppe, Martin Zenke, Rebekka K. Schneider, Sikander Hayat, Turgay Saritas, Rafael Kramann
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-08-01
Online Access:	https://doi.org/10.1038/s41420-024-02131-y