G-Protein-Coupled Receptor Kinase 2 Limits CCL21-Induced T Cell Migration via Phospholipase Cγ1

<b>Background/Objectives</b>: G protein-coupled receptors (GPCRs) can promote ligand-biased signaling, yet the mechanisms that promote bias are not well understood. We have shown that C-C Chemokine Ligand 19 (CCL19) and CCL21 promote ligand-biased internalization and signaling of C-C Che...

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Bibliographic Details

Published in:	Receptors
Main Authors:	Anahi Sanchez, Caitlin T. Winebrenner, Natalia Garcia, Brian Kaiser, Lyndsey Kilgore, Cesar I. Cardona, Daniel W. Bassuk, Mary E. Miller, Charles A. Bill, Laura A. Shannon, Brant M. Wagener, Amy Wagler, Manuel Llano, Colin A. Bill, Charlotte M. Vines
Format:	Article
Language:	English
Published:	MDPI AG 2025-09-01
Subjects:	G protein-coupled receptor kinase ligand-biased signaling chemokine T cell
Online Access:	https://www.mdpi.com/2813-2564/4/3/17