Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition

Abstract Background During metastasis, cancer cells undergo epithelial-mesenchymal transition (EMT) in response to transforming growth factor-β (TGF-β), which is abundant in the tumor microenvironment, and acquire invasive and metastatic potentials. Metastasis to distant organs requires intravascula...

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發表在:	Inflammation and Regeneration
Main Authors:	Miho Kobayashi, Kashio Fujiwara, Kazuki Takahashi, Yusuke Yoshioka, Takahiro Ochiya, Katarzyna A. Podyma-Inoue, Tetsuro Watabe
格式:	Article
語言:	英语
出版:	BMC 2022-09-01
主題:	Extracellular vesicles Epithelial-mesenchymal transition Endothelial-mesenchymal transition Transforming growth factor-β Endothelial barrier Pre-metastatic niches
在線閱讀:	https://doi.org/10.1186/s41232-022-00225-7