Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma

Abstract Sonic hedgehog (Shh)-group medulloblastoma (MB) (Shh-MB) encompasses a clinically and molecularly distinct group of cancers originating from the developing nervous system with aberrant high Shh signaling as a causative driver. We recently reported that RNF220 is required for sustained high...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Yuwei Li, Huishan Wang, Bin Sun, Guifeng Su, Yu Cang, Ling Zhao, Shuhua Zhao, Yan Li, Bingyu Mao, Pengcheng Ma
Format:	Article
Language:	English
Published:	Nature Publishing Group 2023-08-01
Online Access:	https://doi.org/10.1038/s41419-023-06025-2