Peripheral decarboxylase inhibitors paradoxically induce aromatic L-amino acid decarboxylase

Abstract Peripheral decarboxylase inhibitors (PDIs) prevent conversion of levodopa to dopamine in the blood by the enzyme aromatic L-amino acid decarboxylase (AADC). Alterations in enzyme activity may contribute to the required higher dosages of levodopa observed in many patients with Parkinson’s di...

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Bibliographic Details

Published in:	npj Parkinson's Disease
Main Authors:	Anouke van Rumund, Lukas Pavelka, Rianne A. J. Esselink, Ben P. M. Geurtz, Ron A. Wevers, Brit Mollenhauer, Rejko Krüger, Bastiaan R. Bloem, Marcel M. Verbeek
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-03-01
Online Access:	https://doi.org/10.1038/s41531-021-00172-z