GABA/baclofen stabilizes PD-L1 and enhances immunotherapy of breast cancer

The programmed death-ligand 1 (PD-L1) on the surface of tumor cells binds to the receptor programmed cell death protein 1 (PD-1) on effector T cells, thereby inhibiting the anti-tumor immune response. Immune checkpoint blockade (ICB) therapy targeting PD-1/PD-L1 has been approved for the treatment o...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Xue Sun, Mingen Lin, Ziyin Tian, Yan Ma, Lei Lv
Format:	Article
Language:	English
Published:	Elsevier 2024-04-01
Subjects:	GABA Baclofen PD-L1 Immunotherapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844024046310