High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease

Abstract Background Recent advances in blood-based biomarker discovery are paving the way for simpler, more accessible diagnostic tools that can detect early signs of Alzheimer’s disease (AD). Recent successes in the development of amyloid-targeting immunotherapy approaches mark an important advance...

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Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Mohammad Arastoo, Lewis K. Penny, Richard Lofthouse, Aya Abdallah, Anna Abrahamsson, Pietro Marini, Valeria Melis, Gernot Riedel, Charles R. Harrington, Claude M. Wischik, Andrew Porter, Soumya Palliyil
Format:	Article
Language:	English
Published:	BMC 2024-10-01
Subjects:	Alzheimer’s disease Tauopathy Tau protein Paired helical filament Monoclonal antibody Diagnostic
Online Access:	https://doi.org/10.1186/s13195-024-01561-1