Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction

Excessive production of cytokines by microglia may cause cognitive dysfunction and long-lasting behavioral changes. Activating the peripheral innate immune system stimulates cytokine secretion in the central nervous system, which modulates cognitive function. Histone deacetylases (HDACs) modulate cy...

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Bibliographic Details

Published in:	Mediators of Inflammation
Main Authors:	Chung-Hsi Hsing, Shih-Kai Hung, Yeong-Chang Chen, Tsui-Shan Wei, Ding-Ping Sun, Jhi-Joung Wang, Ching-Hua Yeh
Format:	Article
Language:	English
Published:	Wiley 2015-01-01
Online Access:	http://dx.doi.org/10.1155/2015/163140