Indoxyl sulfate induces retinal microvascular injury via COX-2/PGE2 activation in diabetic retinopathy

Abstract Background Diabetic retinopathy (DR), the principal cause of acquired blindness among the working-age population, is the most frequent microvascular complication of diabetes. Although metabolic disorders are hypothesized to play a role in its pathogenesis, the underlying mechanism remains l...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Lan Zhou, Hongyan Sun, Gongyi Chen, Cunzi Li, Dan Liu, Xurui Wang, Ting Meng, Zhenyou Jiang, Shu Yang, Ming-Ming Yang
Format:	Article
Language:	English
Published:	BMC 2024-09-01
Subjects:	Indoxyl sulfate Diabetic retinopathy Microcapillary damage COX-2 PGE2
Online Access:	https://doi.org/10.1186/s12967-024-05654-1