Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver

Orotic acid (OA), an intermediate in pyrimidine metabolism, has been used for a variety of purposes, such as dietary supplements. Although it is well documented that OA induces fatty liver in a species-specific manner, the precise molecular mechanisms remain unclear. The present study investigated t...

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Bibliographic Details

Published in:	Journal of Lipid Research
Main Authors:	Eun-Jeong Jung, Sung-Won Kwon, Byung-Hwa Jung, Seon-Hee Oh, Byung-Hoon Lee
Format:	Article
Language:	English
Published:	Elsevier 2011-09-01
Subjects:	lipidsh toxicology pharmacology adenosine monophosphate-activated protein kinase sterol regulatory element-binding protein-1
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520408533