Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate

Summary: Stemness and pluripotency are mediated by transcriptional master regulators that promote self-renewal and repress cell differentiation, among which is the high-mobility group (HMG) box transcription factor SOX2. Dysregulated SOX2 expression, by contrast, leads to transcriptional aberrations...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Thorsten Schaefer, Nitish Mittal, Hui Wang, Meric Ataman, Silvia Candido, Jonas Lötscher, Sergiy Velychko, Lionel Tintignac, Thomas Bock, Anastasiya Börsch, Jochen Baßler, Tata Nageswara Rao, Jakub Zmajkovic, Sarah Roffeis, Jordan Löliger, Francis Jacob, Alain Dumlin, Christoph Schürch, Alexander Schmidt, Radek C. Skoda, Matthias P. Wymann, Christoph Hess, Hans R. Schöler, Holm Zaehres, Ed Hurt, Mihaela Zavolan, Claudia Lengerke
Format:	Article
Language:	English
Published:	Elsevier 2024-10-01
Subjects:	CP: Developmental biology CP: Molecular biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124724011586