Role of Lysosomes in Silica-Induced Inflammasome Activation and Inflammation in Absence of MARCO

MARCO is the predominant scavenger receptor for recognition and binding of silica particles by alveolar macrophages (AM). Previously, it was shown that mice null for MARCO have a greater inflammatory response to silica, but the mechanism was not described. The aim of this study was to determine the...

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Bibliographic Details
Published in:Journal of Immunology Research
Main Authors: Rupa Biswas, Raymond F. Hamilton, Andrij Holian
Format: Article
Language:English
Published: Wiley 2014-01-01
Online Access:http://dx.doi.org/10.1155/2014/304180