Basis for selective drug evasion of an aminoglycoside-resistance ribosomal RNA modification

Abstract Aminoglycosides disrupt the fidelity of bacterial protein synthesis, but their potent antibacterial activity is threatened by multiple resistance mechanisms, including methylation of their ribosomal RNA (rRNA) binding site. However, the impact of one such resistance-conferring methylation o...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Debayan Dey, Jacob M. Mattingly, Natalia Zelinskaya, Christine M. Dunham, Graeme L. Conn
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Online Access:	https://doi.org/10.1038/s41467-025-63278-5