PEGylation Effects on Amphiphilic Platinum(IV) Complexes: Influence on Uptake, Activation, and Cytotoxicity

<b>Background/Objectives:</b> The utilization of amphiphilic Pt(IV) complexes as prodrugs offers a promising strategy to revolutionize Pt-based cancer therapy by enhancing drug delivery and activation. While PEGylation is widely used to optimize drug properties, its impact on the biologi...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Arpit Sharma, Md Al Amin, Man B. Kshetri, Suha Alqarni, Wjdan Jogadi, Jordan Solmen, Zexin Lin, Shirin Akter, Yao-Rong Zheng
Format:	Article
Language:	English
Published:	MDPI AG 2025-03-01
Subjects:	platinum(IV) prodrugs PEGylation cisplatin mitochondria
Online Access:	https://www.mdpi.com/1999-4923/17/4/440