Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody

The T-cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT) is a validated immune checkpoint protein expressed on memory CD4+T-cellls, Tregs, CD8+T-cell and natural killer (NK) cells. ASP8374 is a fully human monoclonal immunoglobulin (Ig) G4 antibody...

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出版年:	Cancer Treatment and Research Communications
主要な著者:	Kenna Shirasuna, Gerald Koelsch, Cynthia Seidel-Dugan, Andres Salmeron, Philipp Steiner, William M Winston, Heather R Brodkin, Christopher J Nirschl, Sandra Abbott, Fumitaka Kinugasa, Shingo Sugahara, Makoto Ohori, Masahiro Takeuchi, Daniel J Hicklin, Taku Yoshida
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2021-01-01
主題:	Cancer TIGIT Immune checkpoint Immunotherapy
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2468294221001313