Fluorescence Lifetime Imaging Microscopy (FLIM) reveals spatial-metabolic changes in 3D breast cancer spheroids

Abstract Cancer cells are mechanically sensitive to physical properties of the microenvironment, which can affect downstream signaling to promote malignancy, in part through the modulation of metabolic pathways. Fluorescence Lifetime Imaging Microscopy (FLIM) can be used to measure the fluorescence...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Kavon Karrobi, Anup Tank, Mohammad Ahsan Fuzail, Madhumathi Kalidoss, Karissa Tilbury, Muhammad Zaman, Jacopo Ferruzzi, Darren Roblyer
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-03-01
Online Access:	https://doi.org/10.1038/s41598-023-30403-7