Primary sensory neuron dysfunction underlying mechanical itch hypersensitivity in a Shank3 mouse model of autism

Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder marked by social deficits, repetitive behaviors and atypical sensory perception. The link between ASD and skin abnormalities, inducing itchiness, has never been investigated in depth. This study explores mechanical itch sensiti...

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Bibliographic Details

Published in:	Translational Psychiatry
Main Authors:	Damien Huzard, Giulia Oliva, Mélanie Marias, Chloé Granat, Vanessa Soubeyre, Glaécia do Nascimento Pereira, Ahmed Negm, Gawain Grellier, Jérôme Devaux, Emmanuel Bourinet, Amaury François
Format:	Article
Language:	English
Published:	Nature Publishing Group 2025-07-01
Online Access:	https://doi.org/10.1038/s41398-025-03461-w