Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation

The function of intracellular trafficking in immune-complex triggered inflammation remains poorly understood. Here, we investigated the role of Insulin-Regulated Amino Peptidase (IRAP)-positive endosomal compartments in Fc receptor (FcR)-induced inflammation. Less severe FcγR-triggered arthritis, ac...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Manuela Bratti, Shamila Vibhushan, Cyril Longé, Despoina Koumantou, Gaël Ménasché, Marc Benhamou, Nadine Varin-Blank, Ulrich Blank, Loredana Saveanu, Sanae Ben Mkaddem
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	Fc receptors inflammation signaling intracellular trafficking insulin-regulated aminopeptidase
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1029759/full