Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury

Objective: Energy-intensive kidney reabsorption processes essential for normal whole-body function are maintained by tubular epithelial cell metabolism. Although tubular metabolism changes markedly following acute kidney injury (AKI), it remains unclear which metabolic alterations are beneficial or...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	Adam J. Rauckhorst, Gabriela Vasquez Martinez, Gabriel Mayoral Andrade, Hsiang Wen, Ji Young Kim, Aaron Simoni, Claudia Robles-Planells, Kranti A. Mapuskar, Prerna Rastogi, Emily J. Steinbach, Michael L. McCormick, Bryan G. Allen, Navjot S. Pabla, Ashley R. Jackson, Mitchell C. Coleman, Douglas R. Spitz, Eric B. Taylor, Diana Zepeda-Orozco
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Subjects:	Acute kidney injury Hormesis Metabolomics Mitochondrial metabolism Oxidative stress
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877823001837