MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4

Summary: Aging-related cardiac fibrosis represents the principal pathological progression in cardiovascular aging. The Muscleblind-like splicing regulator 2 (MBNL2) has been unequivocally established as being associated with cardiovascular diseases. Nevertheless, its role in aging-related cardiac fi...

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Bibliographic Details

Published in:	iScience
Main Authors:	Jing Lu, Qi Zhao, Lu Wang, Jiahao Li, Hongyan Wang, Lin Lv, Meng Yuan, Qiuyu Chen, Zixin Zhang, Dankun Luo, Siqi Sheng, Keying Yuan, Guannan Liu, Mingyu Liu, Yuanqi Shi, Yuanyuan Guo, Zengxiang Dong
Format:	Article
Language:	English
Published:	Elsevier 2024-07-01
Subjects:	molecular biology omics Transcriptomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224013889