Quantitative comparison of protein-protein interaction interface using physicochemical feature-based descriptors of surface patches

Driving mechanisms of many biological functions in a cell include physical interactions of proteins. As protein-protein interactions (PPIs) are also important in disease development, protein-protein interactions are highlighted in the pharmaceutical industry as possible therapeutic targets in recent...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Woong-Hee Shin, Keiko Kumazawa, Kenichiro Imai, Takatsugu Hirokawa, Daisuke Kihara
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	protein-protein interaction PPI PPI drugs molecular surface protein-protein interaction (PPI) 3D Zernike descriptor
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2023.1110567/full