Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation

Abstract Human natural killer (NK) cell-based therapies are under assessment for treating various cancers, but cryopreservation reduces both the recovery and function of NK cells, thereby limiting their therapeutic feasibility. Using cryopreservation protocols optimized for T cells, here we find tha...

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出版年:	Nature Communications
主要な著者:	Abdulla Berjis, Deeksha Muthumani, Oscar A. Aguilar, Oz Pomp, Omar Johnson, Amanda V. Finck, Nils W. Engel, Linhui Chen, Nicolas Plachta, John Scholler, Lewis L. Lanier, Carl H. June, Neil C. Sheppard
フォーマット:	論文
言語:	英語
出版事項:	Nature Portfolio 2024-05-01
オンライン･アクセス:	https://doi.org/10.1038/s41467-024-47574-0