Human VH4-34 antibodies derived from B1 cells are more frequently autoreactive than VH4-34 antibodies derived from memory cells

Human B1 cells produce natural antibodies characterized by overutilization of heavy chain variable region VH4-34 in comparison to other B cell populations. VH4-34-containing antibodies have been reported to be autoreactive and to be associated with lupus and other autoimmune dyscrasias. However, it...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Michelle E. Ray, Thomas L. Rothstein
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-12-01
Subjects:	B cells antibody autoreactive CDR3 VH4-34 B1 cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1259827/full