A shark-derived broadly neutralizing nanobody targeting a highly conserved epitope on the S2 domain of sarbecoviruses

Abstract The continuously evolving Omicron subvariants has diminished the effectiveness of almost all RBD-targeted antibodies in neutralizing these subvariants. The development of broad-spectrum neutralizing antibodies is desired for addressing both current and future variants. Here, we identified a...

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Bibliographic Details

Published in:	Journal of Nanobiotechnology
Main Authors:	Bo Feng, Cuiyun Li, Zhaoyong Zhang, Yongming Huang, Banghui Liu, Zhengyuan Zhang, Jia Luo, Qian Wang, Li Yin, Si Chen, Ping He, Xiaoli Xiong, Jincun Zhao, Xuefeng Niu, Zhilong Chen, Ling Chen
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Shark nanobody SARS-CoV-2 Sarbecovirus Broad spectrum neutralization
Online Access:	https://doi.org/10.1186/s12951-025-03150-2