Sec61 complex/translocon: The role of an atypical ER Ca2+-leak channel in health and disease

The heterotrimeric Sec61 protein complex forms the functional core of the so-called translocon that forms an aqueous channel in the endoplasmic reticulum (ER). The primary role of the Sec61 complex is to allow protein import in the ER during translation. Surprisingly, a completely different function...

Full description

Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Jan B. Parys, Fabien Van Coppenolle
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	Sec61 complex/translocon reticular Ca2+-leak channel ER stress cell survival apoptosis intracellular Ca2+ homeostasis
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2022.991149/full