Contributions of major tau kinase activation and phospho-tau accumulation to cortical and hippocampal tangle formation and cognition in older adults

Aberrant activation of tau kinases (tauK) has been proposed as a major step in tau hyperphosphorylation and misfolding, and subsequent formation of neurofibrillary tangles (NFT) in Alzheimer's disease (AD). However, evidence of tauK hyperactivation in actual AD brains is scarce and inconsistent...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Elena Hernández-Hernández, Vladislav A. Petyuk, Júlia Valor-Blanquer, Fernando Yáñez-Gómez, Alasdair M. Barr, Philip L. De Jager, Er-Yun Chen, Sue E. Leurgans, Julie A. Schneider, David A. Bennett, William G. Honer, M. Julia García-Fuster, Alfredo Ramos-Miguel
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Subjects:	Alzheimer's disease Working memory Human brain Tau kinase CDK-5 p25/p35
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996125001408