TRIMming down Mycobacterium tuberculosis replication: TRIM32 is required for bacterial ubiquitination and autophagy induction in macrophages

Mycobacterium tuberculosis (Mtb) promotes its intracellular persistence by subverting defense mechanisms, such as autophagy. Remarkably, enhancing autophagy is sufficient to trigger intracellular Mtb killing and effective immune response, making this process a valid target of host-directed therapies...

Full description

Bibliographic Details

Published in:	Autophagy Reports
Main Authors:	Alessandra Romagnoli, Martina Di Rienzo, Mauro Piacentini, Gian Maria Fimia
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Subjects:	Xenophagy TRIM ubiquitin ligases Mycobacterium tuberculosis Ubiquitin
Online Access:	https://www.tandfonline.com/doi/10.1080/27694127.2023.2278120