P2X7 Nucleotide and EGF Receptors Exert Dual Modulation of the Dual-Specificity Phosphatase 6 (MKP-3) in Granule Neurons and Astrocytes, Contributing to Negative Feedback on ERK Signaling

Extracellular signal-regulated kinases 1 and 2 (ERK1/2) play a central role in the intracellular signaling of P2X7 nucleotide receptors in neurons and glial cells. Fine spatio-temporal tuning of mitogen-activated protein (MAP) kinases is essential to regulate their biological activity. MAP kinase ph...

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Bibliographic Details

Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Mª José Queipo, Juan C. Gil-Redondo, Verónica Morente, Felipe Ortega, Mª Teresa Miras-Portugal, Esmerilda G. Delicado, Raquel Pérez-Sen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-01-01
Subjects:	astrocytes DUSP6 ERKs glial cells granule neurons MKP3
Online Access:	http://journal.frontiersin.org/article/10.3389/fnmol.2017.00448/full