TNFα Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model

ABSTRACT Background Painful intervertebral disc (IVD) degeneration (IVDD) involves chronic inflammation. Developing translational immunomodulatory strategies for IVDD is a priority with tumor necrosis factor alpha (TNFα) signaling an important target. TNFα binds to 2 receptors (TNFRs), with TNFR1 si...

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出版年:	JOR Spine
主要な著者:	Timothy D. Jacobsen, S. Olga Yiantsos, Jennifer Gansau, James Meyers, Damien Laudier, James C. Iatridis
フォーマット:	論文
言語:	英語
出版事項:	Wiley 2025-06-01
主題:	Atsttrin Cell Culture ErythrosineB inflammation intervertebral disc degeneration Physcion‐8‐O‐β‐D‐monoglucoside
オンライン･アクセス:	https://doi.org/10.1002/jsp2.70070