Targeting of retrovirus-derived Rtl8a/8b causes late-onset obesity, reduced social response and increased apathy-like behaviour

Retrotransposon Gag-like (RTL) 8A, 8B and 8C are eutherian-specific genes derived from a certain retrovirus. They cluster as a triplet of genes on the X chromosome, but their function remains unknown. Here, we demonstrate that Rtl8a and Rtl8b play important roles in the brain: their double knockout...

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Bibliographic Details

Published in:	Open Biology
Main Authors:	Yoshifumi Fujioka, Hirosuke Shiura, Masayuki Ishii, Ryuichi Ono, Tsutomu Endo, Hiroshi Kiyonari, Yoshikazu Hirate, Hikaru Ito, Masami Kanai-Azuma, Takashi Kohda, Tomoko Kaneko-Ishino, Fumitoshi Ishino
Format:	Article
Language:	English
Published:	The Royal Society 2025-01-01
Subjects:	retrovirus-derived genes neuronal development social response apathy late-onset obesity Prader–Willi syndrome
Online Access:	https://royalsocietypublishing.org/doi/10.1098/rsob.240279