Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis

This study reports on the synthesis and evaluation of novel compounds replacing the nitrogen-containing heterocyclic ring on the chemical backbone structure of cytochrome P450 17α-hydroxylase/12,20-lyase (CYP17A1) inhibitors with a phenyl bearing a sulfur-based substituent. Initial screening reveale...

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发表在:	Biomolecules
Main Authors:	Tomasz M. Wróbel, Katyayani Sharma, Iole Mannella, Simonetta Oliaro-Bosso, Patrycja Nieckarz, Therina Du Toit, Clarissa Daniela Voegel, Maria Natalia Rojas Velazquez, Jibira Yakubu, Anna Matveeva, Søren Therkelsen, Flemming Steen Jørgensen, Amit V. Pandey, Agnese C. Pippione, Marco L. Lolli, Donatella Boschi, Fredrik Björkling
格式:	文件
语言:	英语
出版:	MDPI AG 2023-09-01
主题:	CYP17A1 AKR1C3 prostate cancer enzyme inhibition
在线阅读:	https://www.mdpi.com/2218-273X/13/9/1349