Integrated multi-omics reveal lactate metabolism-related gene signatures and PYGL in predicting HNSCC prognosis and immunotherapy efficacy

Abstract Background Head and neck squamous cell carcinoma (HNSCC) treatment faces significant clinical challenges. Lactate metabolism plays a crucial role in the initiation of many cancers and the tumor microenvironment (TME). However, the prognostic significance of lactate metabolism-related genes...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Xiaochuan Chen, Zhangying Jiang, Junping Pan, Wenqian Xu, Ying Li, Xin Chen, Yuhui Pan, Youliang Weng, Dan Hu, Sufang Qiu
Format: Article
Language:English
Published: BMC 2025-04-01
Subjects:
Head and neck squamous cell carcinoma
Lactate metabolism
Tumor microenvironment
Prognostic model
PYGL
Online Access:https://doi.org/10.1186/s12885-025-13982-8

Internet

https://doi.org/10.1186/s12885-025-13982-8

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