Cilengitide inhibits osteoclast adhesion through blocking the αvβ3-mediated FAK/Src signaling pathway

The remodeling of actin cytoskeleton of osteoclasts on the bone matrix is essential for osteoclastic resorption activity. A specific regulator of the osteoclast cytoskeleton, integrin αvβ3, is known to provide a key role in the degradation of mineralized bone matrixes. Cilengitide is a potent inhibi...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Dan-yang Guo, Zhong-hua Chen, Yi-fei Fu, Yue-yue Li, Meng-nan Chen, Jun-jie Wu, Zheng-dong Yuan, Jun-Xing Ye, Xia Li, Feng-lai Yuan
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Subjects:	Cilengitide Osteoclast Integrin αvβ3 Adhesion FAK/Src signaling
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844023050491