Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk.

Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging, were recently shown to be associated with Alzheimer disease (AD) risk in cognit...

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Published in:	PLoS ONE
Main Authors:	Muhammad Ali, Yun Ju Sung, Fengxian Wang, Maria V Fernández, John C Morris, Anne M Fagan, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleó, Daniel Alcolea, Jordi Clarimon, Lorena Rami, José Luis Molinuevo, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Christian Haass, Michael Ewers, Johannes Levin, Martin R Farlow, Richard J Perrin, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN), Carlos Cruchaga
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2022-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0267298