Deep behavioral phenotyping tracks functional recovery following tibia fracture in mice

IntroductionAn estimated 178 million fractures occur worldwide annually, with lower limb fractures showing high rates of poor healing, often resulting in reduced mobility and chronic pain. Bone healing and the ability to bear weight are closely tied to the mechanical stability of the fracture site....

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Jonathan E. Layne, Dustin M. Snapper, Molly E. Czachor, Charles Lam, Jacob D. Matityahu, Dane R. G. Lind, Matthieu Huard, Johnny Huard, Kazuhito Morioka, Julian C. Motzkin, Allan I. Basbaum, Jarret A. P. Weinrich, Chelsea S. Bahney
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	behavioral phenotyping fracture repair fracture-related pain machine-learning image analysis sexual dimorphism
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2025.1630155/full