H- and m-channel overexpression promotes seizure-like events by impairing the ability of inhibitory neurons to process correlated inputs.
Channelopathies affecting the hyperpolarization-activated cyclic nucleotide gated (HCN or h-) channel and the Kv7 voltage gated m-type potassium (m-) channel present a paradox in epilepsy research: despite experimental evidence that both over- and underexpression of these channels can be epileptogen...
| الحاوية / القاعدة: | PLoS Computational Biology |
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| المؤلفون الرئيسيون: | , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
Public Library of Science (PLoS)
2025-06-01
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| الوصول للمادة أونلاين: | https://doi.org/10.1371/journal.pcbi.1013199 |