Pharmacological activation of the hERG K+ channel for the management of the long QT syndrome: A review

Abstract In the human heart, the rapid delayed rectifier K+ current (IKr) contributes significantly to ventricular action potential (AP) repolarization and to set the duration of the QT interval of the surface electrocardiogram (ECG). The pore‐forming (α) subunit of the IKr channel is encoded by KCN...

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Bibliographic Details

Published in:	Journal of Arrhythmia
Main Authors:	Aziza El Harchi, Oriane Brincourt
Format:	Article
Language:	English
Published:	Wiley 2022-08-01
Subjects:	Long QT syndrome hERG K+ channel pharmacology mutation arrhythmia hERG agonists
Online Access:	https://doi.org/10.1002/joa3.12741