Structural study reveals the temperature-dependent conformational flexibility of Tk-PTP, a protein tyrosine phosphatase from Thermococcus kodakaraensis KOD1.

Protein tyrosine phosphatases (PTPs) originating from eukaryotes or bacteria have been under intensive structural and biochemical investigation, whereas archaeal PTP proteins have not been investigated extensively; therefore, they are poorly understood. Here, we present the crystal structures of Tk-...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Hye-Yeoung Yun, Jinhyuk Lee, Hyunmin Kim, Hyojung Ryu, Ho-Chul Shin, Byung-Ha Oh, Bonsu Ku, Seung Jun Kim
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-01-01
Online Access:	http://europepmc.org/articles/PMC5965843?pdf=render