Flavivirus NS4B proteins do not form homodimers: discrepancies with an AlphaFold-based oligomeric model

In flaviviruses such as Dengue, Zika or West Nile virus (DENV, ZIKV or WNV), non-structural protein 4B (NS4B) participates in membrane remodeling during infection and is critical for virulence and host immunity. Despite the important roles and confirmed drug target status for NS4B, no detailed struc...

Full description

Bibliographic Details

Published in:	Computational and Structural Biotechnology Journal
Main Authors:	Wahyu Surya, Paula Tan, Shwe Sin Honey, Devanshu Mehta, Jaume Torres
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	Flavivirus Dengue Zika Non-structural protein 4B Oligomerization AlphaFold
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037025001497