Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Understanding the immune compartment of tumors facilitates the development of revolutionary new therapies. We used a Kras(G12D)-driven mouse model of lung cancer to establish an immune signature and identified a contribution of Gr1+ neutrophils to disease progression. Depletion experiments showed th...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Julien Faget, Svenja Groeneveld, Gael Boivin, Martial Sankar, Nadine Zangger, Miguel Garcia, Nicolas Guex, Inti Zlobec, Loïc Steiner, Alessandra Piersigilli, Ioannis Xenarios, Etienne Meylan
Format:	Article
Language:	English
Published:	Elsevier 2017-12-01
Subjects:	lung cancer neutrophil MegaClust vascularization hypoxia immunotherapy PD1 immune exclusion Snail CXCL2
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124717317047