Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells.

<h4>Background</h4>Recent studies show the importance of interactions between CD47 expressed on acute myeloid leukemia (AML) cells and the inhibitory immunoreceptor, signal regulatory protein-alpha (SIRPα) on macrophages. Although AML cells express SIRPα, its function has not been invest...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Mahban Irandoust, Julian Alvarez Zarate, Isabelle Hubeek, Ellen M van Beek, Karin Schornagel, Aart J F Broekhuizen, Mercan Akyuz, Arjan A van de Loosdrecht, Ruud Delwel, Peter J Valk, Edwin Sonneveld, Pamela Kearns, Ursula Creutzig, Dirk Reinhardt, Eveline S J M de Bont, Eva A Coenen, Marry M van den Heuvel-Eibrink, C Michel Zwaan, Gertjan J L Kaspers, Jacqueline Cloos, Timo K van den Berg
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23320069/?tool=EBI