Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells.

Moderate DNA damage resulting from metabolic activities or sub-lethal doses of exogenous insults may eventually lead to cancer onset. Human 46BR.1G1 cells bear a mutation in replicative DNA ligase I (LigI) which results in low levels of replication-dependent DNA damage. This replication stress elici...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Paolo Cremaschi, Matteo Oliverio, Valentina Leva, Silvia Bione, Roberta Carriero, Giulia Mazzucco, Andrea Palamidessi, Giorgio Scita, Giuseppe Biamonti, Alessandra Montecucco
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Online Access:	http://europepmc.org/articles/PMC4495043?pdf=render